Effect of tobacco usage on surgical site wound problems after primary total hip and total knee arthroplasty: A meta-analysis

The meta-analysis aims to assess and compare the effect of tobacco usage on surgical site wound problems (SSWPs) after primary total hip and total knee arthroplasty (PTH & TKA). Using dichotomous random- or fixed-effects models, the outcomes of this meta-analysis were examined, and the odds ratio (OR) with 95% confidence intervals (CIs) was computed. Fifteen studies from 2001 to 2023 were enrolled for the present meta-analysis including 560 819 personals with PTH & TKA. Smokers had significantly higher SSWPs (OR, 1.53; 95% CI, 1.21-1.94, p < 0.001) compared with non-smokers in personals with PTH & TKA. Current smokers had significantly higher SSWPs (OR, 1.59; 95% CI, 1.40-1.80, p < 0.001) compared with non-smokers in personals with PTH & TKA. Current smokers had significantly higher SSWPs (OR, 1.42; 95% CI, 1.19-1.70, p < 0.001) compared with former smokers in personals with PTH & TKA. However, former smokers and non-smokers had no significant difference in SSWPs (OR, 1.11; 95% CI, 0.95-1.30, p = 19) in personals with PTH & TKA. The examined data revealed that in personals with PTH & TKA smokers had significantly higher SSWPs compared with non-smokers, and current smokers had significantly higher SSWPs compared with non-smokers and former smokers; however, former smokers and non-smokers had no significant difference in SSWPs. Yet, attention should be implemented while relating to its values since some of the comparisons were made using a low number of selected studies.