Chance of Pregnancy Not Decreased With Increasing Time Duration Between Ultrasound and Trigger Shot in Insemination Cycles

INTRODUCTION: Follicle growth is often estimated during intrauterine insemination (IUI) ultrasounds in order to benefit the patient financially and decrease the number of appointments. There is a paucity of research evaluating the risks of increasing time duration between last ultrasound and ovulation induction. We sought to explore this research question further using clinical pregnancy rate as the primary outcome. METHODS: A retrospective cohort study was performed utilizing the UCHealth Center for Reproductive Health IUI database (November 2021 to June 2022). Patient population includes women with history of polycystic ovarian syndrome and infertility. The main variable evaluated was the interval time (day[s]) between the final ultrasound of the ovulation induction cycle and the date of trigger shot. Primary outcome measured is clinical pregnancy rate (CPR). Chi-square analysis was used to determine a significant relationship between the data sets. RESULTS: A total of 324 cycles were included. There was a statistical difference in CPR (12.77% versus 34%, P =.000) when comparing the interval of less than 3 days versus greater than 3 days, respectively. There was also a statistical difference in CPR (10.99% versus 23.31%, P =.003) when comparing the interval of less than 2 days versus greater than 2 days, respectively. CONCLUSION: Increasing time between the final ultrasound date and the date of trigger shot does not decrease the rate of clinical pregnancy. Further research should be done, incorporating a larger sample size and increasing population diversity.