Inpatient mobility to predict hospital-onset Clostridium difficile: a network approach

crossref(2018)

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摘要
AbstractWith hospital-onset Clostridium difficile Infection (CDI) still a common occurrence in the U.S., this paper examines the relationship between unit-wide CDI susceptibility and inpatient mobility and creates a predictive measure of CDI called “Contagion Centrality”. A mobility network was constructed using two years of patient electronic health record (EHR) data within a 739-bed hospital (Jan. 2013 - Dec. 2014; n=72,636 admissions). Network centrality measures were calculated for each hospital unit (node) providing clinical context for each in terms of patient transfers between units (edges). Daily unit-wide CDI susceptibility scores were calculated using logistic regression and compared to network centrality measures to determine the relationship between unit CDI susceptibility and patient mobility. Closeness centrality was a statistically significant measure associated with unit susceptibility (p-value < 0.05), highlighting the importance of incoming patient mobility in CDI prevention at the unit-level. Contagion Centrality (CC) was calculated using incoming inpatient transfer rates, unit-wide susceptibility of CDI, and current hospital CDI infections. This measure is statistically significant (p-value <0.05) with our outcome of hospital-onset CDI cases, and captures the additional opportunities for transmission associated with inpatient transfers. We have used this analysis to create an easily interpretable and informative clinical tool showing this relationship and risk of hospital-onset CDI in real-time. Quantifying and visualizing the combination of inpatient transfers, unit-wide risk, and current infections help identify hospital units at risk of developing a CDI outbreak, and thus provide clinicians and infection prevention staff with advanced warning and specific location data to concentrate prevention efforts.
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