Pd36-03 vesical imaging reporting and data system (vi-rads) could predict the prognosis of bladder cancer patients received radical cystectomy

You have accessJournal of UrologyCME1 Apr 2023PD36-03 VESICAL IMAGING REPORTING AND DATA SYSTEM (VI-RADS) COULD PREDICT THE PROGNOSIS OF BLADDER CANCER PATIENTS RECEIVED RADICAL CYSTECTOMY Qiang Lv, Xiao Yang, Qiang Cao, and Juntao Zhuang Qiang LvQiang Lv More articles by this author , Xiao YangXiao Yang More articles by this author , Qiang CaoQiang Cao More articles by this author , and Juntao ZhuangJuntao Zhuang More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003334.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Vesical Imaging Reporting and Data System (VI-RADS) has shown a good potential in determining muscle-invasive bladder cancer (MIBC) patients. However, whether the VI-RADS could predict the prognosis of radical cystectomy (RC) patients has not been reported. METHODS: We retrospectively analyzed the information of bladder cancer patients admitted to our center from June 2012 to June 2022. All patients who underwent multiparametric magnetic resonance imaging (mpMRI) and underwent RC were included. The exclusion criteria were: 1) Pathology was not urothelial carcinoma. 2) Receive neoadjuvant chemotherapy. 3) VI-RADS could not be evaluated. 4) The follow-up data was incomplete. VI-RADS were scored by two radiologists, blinded to clinical data. Patients’ clinical features, pathology data and imaging information were recorded. All statistical analyses were performed in SPSS26.0 and R software. RESULTS: Overall, 219 patients were finally included in the study. There were 188 males and 31 females with a median age of 66 (IQR: 61-74) years. Pathology showed 23 patients of low grade and 196 cases of high grade. Among them, 126 patients were MIBC. Patients with VI-RADS≥3 had worse progression-free survival (PFS) and overall survival (OS) than those with VI-RADS <3. In addition, we divided into two groups with a cut-off of VI-RADS 4, and found the same trends. The AUC of VI-RADS predicting 3-year PFS was 0.822 (sensitivity=0.832 and negative predictive value=0.923). Multivariate COX regression analysis showed that VI-RADS≥3 and lymph node metastasis were independent risk factors for PFS (HR=2.871, p=0.029 and HR=3.886, p<0.001, respectively). The results of COX regression are shown in Table 1. In the MIBC subgroup, patients with VI-RADS≥4 had worse PFS and OS. In the NMIBC subgroup, the prognosis of patients with VI-RADS≥3 is still worse. VI-RADS was no significance to distinguish the prognosis if patients had multi-walled. CONCLUSIONS: The prognosis of RC patients with VI-RADS≥3 is worse than those with VI-RADS <3. Even if the pathology is NMIBC, the prognosis of them is still worse. In patients with multi-walled tumors, VI-RADS was less valuable in predicting prognosis. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e980 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Qiang Lv More articles by this author Xiao Yang More articles by this author Qiang Cao More articles by this author Juntao Zhuang More articles by this author Expand All Advertisement PDF downloadLoading ...