Differential effects of sleep on brain structure and metabolism at the preclinical stages of AD.

Laura Stankeviciute,Carles Falcon,Grégory Operto,Marina Garcia,Mahnaz Shekari,Álex Iranzo,Aida Niñerola-Baizán,Andrés Perissinotti,Carolina Minguillón,Karine Fauria,Jose Luis Molinuevo,Henrik Zetterberg,Kaj Blennow,Marc Suárez-Calvet,Raffaele Cacciaglia,Juan Domingo Gispert,Oriol Grau-Rivera

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

Poor sleep quality may impact brain structure and function independently from AD pathology. Alternatively, AD-related neurodegeneration in areas involved in sleep-wake regulation may induce or worsen sleep disturbances. Highlights Poor sleep impacts brain structure and function independent of Alzheimer's disease (AD) pathology. Poor sleep exacerbates brain changes observed in preclinical AD. Sleep is an appealing therapeutic strategy for preventing AD.

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关键词

cerebrospinal fluid biomarkers, fluorodeoxyglucose positron emission tomography, preclinical Alzheimer's disease, sleep, structural magnetic resonance imaging

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