TEV/FEV₃ as a coherent metric of small airway dysfunction in childhood asthma.
Allergy and asthma proceedings(2023)
摘要
Spirometry is an unrivalled tool for determining asthma and asthma severity. The ratio of forced expiratory volume (FEV) in 1 second (FEV) to forced vital capacity (FVC) and the forced expiratory flow between 25% and 75% of FVC (FEF) are well-known markers of airway obstruction, but they are limited by low reproducibility, particularly in children. In this study, we defined terminal expiration volume (TEV) as FEV in 3 seconds forced expiratory volume in 3 seconds (FEV₃) minus forced expiratory volume in 1 seconds (FEV) and investigate whether TEV/FEV₃ can function as a coherent marker to compensate for existing markers. This retrospective study comprised 980 children ages ≤ 18 years who underwent spirometry and the bronchial provocation testing. TEV/FEV₃ was compared with regard to asthma presence and severity. The findings were verified with an external validation group (n = 105). FEV₃ was obtained in 837 children (85.4%). TEV/FEV₃ was significantly higher in patients with asthma than in patients who did not have asthma (17.1 ± 5.5 versus 12.0 ± 4.4, p < 0.001). External validation with 73 patients showed similar results (18.0 ± 5.9 in asthma versus 10.2 ± 5.1 in non-asthma, p < 0.001). The discriminatory power of TEV/FEV₃ for asthma was comparable with that of FEF (p = 0.804). TEV/FEV₃ significantly increased with asthma severity (mild, 16.1 ± 5.4; moderate, 17.7 ± 5.4; severe, 22.0 ± 5.3; p < 0.001). For patients who could not achieve FEV₃, FEF demonstrated no significant difference between mild and moderate asthma, and could not discriminate asthma or asthma severity. TEV/FEV₃ is a new metric that may help diagnose and determine asthma severity by using conventional spirometry by assessing small airway dysfunction. TEV/FEV₃ promotes a reassessment of the reliability of other spirometric parameters, particularly in young children. Caution is needed in interpreting the result of spirometry in children who cannot achieve FEV₃.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要