Po-05-198 in-hospital outcomes of pregnant women with long qt syndrome – insights from the national inpatient sample.

Patients admitted with a history of long QT syndrome (LQTS) have a higher all-cause mortality when compared to the general population, a trend especially pronounced among males. Conversely, in pregnant women the risk of potentially life-threatening events is lower during pregnancy but increases significantly during the 9-month postpartum period, however, limited data exists. To describe the baseline demographics and in-hospital outcomes of adult (≥ 18 years old) pregnant women with a previous diagnosis of LQTS. The National Inpatient Sample Database was queried from 2016-2019 for relevant ICD-10 diagnostic and procedural codes to construct our cohort. Outcomes of interest included frequency of ventricular tachycardia and in-hospital all-cause mortality. A total of 513,890 patients with a diagnosis of LQTS were identified, of which 3,285 (0.6%) were pregnant women (average age 28.8 years; 56% white). Asthma (13%) and obesity (12%) were the most common comorbidities, followed by heart failure (5%), diabetes mellitus (4%), OSA (1.4%), and coronary artery disease (1.4%). Substance use disorder was reported in 14% subjects and 15.6% had an implanted cardiac device at the time of admission. For obstetric comorbidities, the most common was preeclampsia (8%) and stillbirth (0.8%). There was a prevalence of 2% for ventricular tachycardia and 0.3% inpatient all-cause mortality. Among patients admitted with LQTS, pregnant women represent a significantly high-risk cohort for adverse cardiac and non-cardiac events for both mother and child. A multidisciplinary approach to identify these patients early is critical to improving maternal-fetal outcomes.