Fabrication and evaluation of antimicrobial cellulose/Arabic gum hydrogels as potential drug delivery vehicle
International Journal of Biological Macromolecules(2023)
摘要
This article aims to assess the highly potent antimicrobial hydrogels composed of cellulose and Arabic gum containing sulfadiazine drug (sulfadiazine-loaded Cel/AG) as drug-targeting carriers. ATR-IR, SEM/ EDS, XRD, and XPS methods were used to investigate the hydrogel. The highest water absorption % was 489.93 & PLUSMN; 4.5 at pH 7.4. Pseudo-second order and Fickian diffusion govern the swelling behavior. The maximal sulfadiazine loading percent was 82.291 & PLUSMN; 74. The in-vitro drug release exhibited significant responses in physiologically simulated pH values. The maximum cumulative release percent was 66.42 & PLUSMN; 0.6 % at pH 7.4. The drug release is predicted by the first order and Korsmeyer-Peppas models. The first diffusion coefficient was (Di = 9.207 & PLUSMN; 47 x 10-3 cm2/h) and the late one was (DL = 5.64 & PLUSMN; 9.0 x 10-2 cm2/h) at pH 7.4. That hydrogel is well-thought-out a potential drug delivery vehicle. The thermal stability of the Cel/AG hydrogel drug carrier has been enhanced by the incorporation of sulfadiazine which is evidenced by increasing the total activation approximately two-fold. The total activation energy of Cel/AG and sulfadiazine-loaded Cel/AG hydrogels were-0.07362 and-0.2092 J/ mol. The sulfadiazine medication's inhibitory effect was markedly enhanced when it was incorporated into the Cel/AG hydrogel films.
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关键词
Cellulose,Sulfadiazine,Antimicrobial hydrogel
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