Lactobacillus Casei Shirota Probiotic Drinks Reduce Antibiotic Associated Diarrhoea In Patients With Spinal Cord Injuries Who Regularly Consume Proton Pump Inhibitors: A Sub-Group Analysis Of The Eclisp Study.

Rationale: Antibiotic associated diarrhoea (AAD) is of major clinical concern in spinal cord injury (SCI) rehabilitation. Neurogenic bladder dysfunction as a result of SCI often leads to enhanced risk of urinary tract infections.1 Use of invasive devices such as urinary catheters further increases the need for antibiotics and the risks of AAD.2 The ECLISP study found that probiotic (Lactobacillus casei Shirota: LcS) has the potential to prevent AAD in SCI patients who are on proton pump inhibitors (PPI).3 In order to confirm this effects and fully demonstrate the extent of LcS effectiveness in preventing AAD, a sub-group analysis was performed.