Associations between the ICAM1 gene polymorphisms and atherosclerotic cardiovascular disease risk, including hypercholesterolemia, in rural Thais

Abstract We determine the relationships between single nucleotide polymorphisms (SNPs), including rs5498 and rs287432 on Intercellular adhesion molecule 1 gene (ICAM1) and atherosclerotic cardiovascular disease (ASCVD) susceptibility in patients with hypercholesterolemia (HCL). The clinical characteristics of 278 participants were assessed, classified to group having HCL and without HCL. ICAM1 SNPs Genotyping was performed by DNA sequencing and ICAM1 expression was measured using real-time PCR. Positive dominant model rs5498 subjects had twice the risk of HCL (P = 0.005). Participants with the rs5498 AG or GG variants and high ICAM1 mRNA expression (≥ 3.12) had 2.68 times the risk (P = 0.000), and those with a high LDL-C concentration (≥ 3.36 mmol/L) had 1.99 times the risk (P = 0.014) of developing ASCVD compared with those with low ICAM1 mRNA and LDL-C levels. Interestingly, participants carrying the rs5498 AG or GG variants who had tachycardia (resting heart rates (RHRs) > 100 beats/min) had a 5.40-times higher risk than those with a lower RHR (P = 0.010). It may consider the G allele in ICAM1 rs5498 is associated with a higher risk of ASCVD in Thai people with HCL, and is also positively associated with ICAM1 mRNA expression, LDL-C concentration, and RHR.