The association between polymorphisms in long non-coding RNA and lung cancer in non-smoking women

Abstract Background The relationship between long non-coding RNA and lung cancer has become a research hotspot. Methods Four polymorphisms, including rs10188946, rs11246867, rs2288947, and rs8105637 were evaluated in 556 patients with lung cancer and 395 age-matched controls in the present study. Results This study showed that the associations of the four polymorphisms of long non-coding RNA with the risks of lung cancer were not statistically significant. In the age stratification study, AG of rs2288947 was associated with the reduce risk of both lung cancer and adenocarcinoma (OR = 0.597,P = 0.017 and OR = 0.506, P = 0.005,respectively), and AG of rs8105637 was also protected both lung cancer and adenocarcinoma (OR = 0.636,P = 0.037and OR = 0.577, P = 0.023,respectively). We found that when the risk genotypes of the three SNPs rs10188946, rs11246867, rs2288947 and oil exposure worked together, the risk of lung cancer was higher than either of these two risk factors acted alone. Conclusions Four polymorphisms (including rs10188946, rs11246867, rs2288947, and rs8105637) were not associated with lung cancer risks in the present study. After age stratification, rs2288947 and rs8105637 were associated with the risks of lung cancer and adenocarcinoma among the individuals older than 60.