S100A6 Promotes the Development and Apoptosis of Thyroid Cancer Through the PI3K/AKT/Mtor Pathway

Abstract BackgroundThyroid cancer(TC) is the most common endocrine malignant tumor.High levels of S100A6 have been associated with progression in some type of human cancers, but its role in the molecular pathogenesis of these cancers is largely unknown. This study investigated the expression and functional roles of S100A6 in human thyroid cancer. MethodsTCGA database and qRT-PCR were used to examine the expression of S100A6 in thyroid cancer. CCK-8 assay, colony formation assay, Transwell assay, invasion assay and western blot assay were used to identify the biological function of S100A6 in thyroid cancer cells. Flow cytometry is used to assess apoptosis.ResultsCompared with normal thyroid tissues, S100A6 is overexpressed in thyroid cancer tissues and cell lines. Silencing S100A6 can inhibit the proliferation, migration and invasion of TC cells, and induce their apoptosis. ConclusionsS100A6 promotes the progression of thyroid cancer through PI3K/AKT/mTOR pathway and can be used as a target in the future treatment of thyroid cancer.