Systematic Quantitative Evaluation of Plan-IQ for Intensity-Modulated Radiation Therapy After Modified Radical Mastectomy

Abstract Background and purpose: A systematic quantitative evaluation of the quality change of intensity-modulated radiation therapy (IMRT) using the Plan-IQ feasibility tool was performed for modified radical mastectomy.Materials and methods: We selected 50 patients with breast cancer treated with IMRT. All patients received the same dose in the planning target volume (PTV). Two plans were designed for each patient: the clinically accepted normal plan group (NP group) and the repeat plan group (RP group). An automated planning strategy was generated using a Plan-IQ feasibility dose volume histogram (FDVH) in RP group. These plans were assessed according to the dosimetry parameters. A detailed scoring strategy was based on the RTOG9804 report and 2018 National Comprehensive Cancer Network guidelines, combined with clinical experience.Results: PTV coverage in both groups was achieved at 100% of the prescribed dose. Except for the thyroid coverage, the dose limit of organs at risk (OAR) in RP group was significantly better than that in NP group. In the scoring analysis, the total score of RP group decreased compared to that of NP group (P < 0.05), and the individual scores of PTV and OAR significantly changed. PTV score in RP group decreased (P < 0.01); however, OAR score improved (P < 0.01).Conclusions: The Plan-IQ FDVH was useful for evaluating a class solution for IMRT planning. Plan-IQ can automatically help physicians design the best OAR protection plan, which sacrifices part of PTV, while still meeting clinical requirements.