Determinants and consequences of obesity-contribution of the French NutriNet-Sante cohort

Large-scale observational epidemiological studies provide essential information for the development of prevention policies for chronic diseases such as obesity. Since 2009, the French NutriNet-Sante cohort has been used as the basis for 29 empirical studies on obesity. The aim of this review is to present a summary of the findings of those studies and to deduce the contribution of NutriNet-Sante to the understanding of obesity. Among the 29 studies, 5 analyzed obesity as an exposure variable, 23 - as an outcome, and 1 - as a moderator. When modelled as a determinant (or exposure), obesity was cross-sectionally and positively associated with migraine and functional dyspepsia, respectively. In turn, when modelled as a consequence (or outcome), obesity was positively associated with different dietary factors, such as the proportion of ultra-processed foods in the diet and preference for fatty food. Other factors were inversely associated with obesity, such as following an organic diet. Some psychological factors were positively (e.g. impulsivity) or inversely associated (e.g. optimism) with obesity risk. In NutriNet-Sante, further studies on obesity are underway, dealing with its association with COVID-19 and mental disorders.(c) 2022 Societe francaise de nutrition. Published by Elsevier Masson SAS. All rights reserved.