The Association Between Bisphenol A Exposure And The Risk Of Congenital Heart Defects Occurrence In Offspring: A Multi-hospital Case-control Study in China

Abstract Background To examine the association between Bisphenol A (BPA) levels of maternal serum during pregnancy and the occurrence of infant congenital heart defects (CHDs). Method A hospital-based case-control study was performed with samples collected from 2010 to 2014. BPA levels in maternal serum were obtained by Enzyme-Linked Immunosorbent Assay (ELISA). Data from medical records with infant congenital heart defects were collected. Logistic regression analysis was employed to examine the association between maternal BPA exposure and fetal CHD adjusted for confounders (including maternal age and pre-pregnancy body mass index, etc.). Results In total, 524 pregnant women were included in this study. Median (inter-quartile range) BPA levels of maternal serum from the control group and CHD group were 4.6868 (1.6555–8.8338) ng/ml and 4.4641 (1.5902–8.7714) ng/ml, respectively. No association was detected between increased maternal serum BPA concentration and various CHDs phenotype groups, total cases group (aOR 1.003, 95% CI 0.983–1.023), cases having CHDs only (aOR 1.003, 95% CI 0.980–1.026), cases suffering from CHD as well as other defects (aOR 1.002, 95% CI 0.974–1.032), single-subtype CHD (aOR 1.007, 95% CI 0.978–1.037), multiple-subtypes CHDs (aOR 1.002, 95% CI 0.980–1.025). Conclusion Maternal BPA exposure is not significantly correlated with the risk of fetal CHD.