#6192 cognitive dysfuntion and associated risk factors in peritoneal patients

Abstract Background and Aims Patients with cognitive dysfunction (CD)are at greater risk of having a poor quality of life, hospitalization and mortality. Although CD in chronic kidney disease is current, most of the studies performed are cross-sectional. The aim of this cross-sectional study was to determine the presence of CD in the patients on peritoneal dialysis (PD)and to identify possible risk factors associated with CD. Method We performed a study to evaluate the CD of 30 PD patients in our institution using the mini-mental state (MMSE), and a score of <25 was considered to indicate cognitive dysfunction. Demographic, clinical and laboratory parameters, adequacy of dialysis and drugs were analyzed. The statistical analysis included the chi-square test, t-test of independent samples, Mann-Whitney, and correlation. Results We evaluated 30 patients mean age of 57.27 years (SD±12.086); 56.7% were male. About 66.7% of our patients were in marriage, 73.3% were not actively working, 13.3 had a lower level of education, and 56.7% lived in a city. The most prevalent comorbidities were glomerulonephritris and hypertension, both with 30.0%. 19 (57.6%) patients had average fast membrane characteristics. 15 of them (50%) had a daily dose of calcium phosphate binder >2g.MMSE test with a score lower than 25 was present in 36,7% of patients (IQR=4). Statistical analysis revealed a positive correlation between MMSE and weekly total Kt/V urea index (WTKt/V), and the t-test of independent samples showed that patients with better MMSE score values have significantly higher average WTKt/V values (t=-3.062, p<0.011). Conclusion MMSE test with a score less than 25 was present in 36.7% of patients and patients with better MMSE scores have significantly higher average WTKt/V values.