Enhancing biomechanical stimulated Brillouin scattering imaging with physics-driven model selection
arXiv (Cornell University)(2023)
摘要
Brillouin microscopy is an emerging technique for all-optical biomechanical
imaging without the need for physical contact with the sample or for an
external mechanical stimulus. However, Brillouin microscopy often retrieves a
single, averaged Brillouin frequency shift of all the materials in the sampling
volume, introducing significant spectral artifacts in the Brillouin shift
images produced. To enable the identification between single- and multi-peak
Brillouin signatures in the sample voxels, we developed here a new
physics-driven model selection framework based on information theory and an
overfit Brillouin water peak threshold. The model selection framework was
applied to Brillouin data of NIH/3T3 cells measured by stimulated Brillouin
scattering microscopy, facilitating the improved quantification of the
Brillouin shift of different regions in the cells, and substantially minimizing
spectral artifacts in their Brillouin shift images.
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关键词
stimulated brillouin scattering,imaging,physics-driven
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