Supplementary figures and tables from A Global and Integrated Analysis of CINSARC-Associated Genetic Defects

Supplementary figures 1-3 and tables 1-5. Supplementary figure 1. Survival analysis of the 77 cases using the FNCLCC grading system (grade 1 and 2 versus grade 3). Supplementary figure 2. WGD refers to whole genome doubling; CNA refers to copy-number alteration; ITH refers to intra-tumour heterogeneity. Supplementary figure 3. WGD refers to whole genome doubling; CNA refers to copy-number alteration; Meth refers to methylation; ITH refers to intra-tumour heterogeneity. Supplementary table 1. Clinical information for the 77 cases. Supplementary table 2. Genomic coordinates of the 13 differentially (adjusted P < 0.05 and absolute M-value difference > 1) methylated probes with distances from nearest CpG islands and transcription start site. Supplementary table 3. Enrichment for CINSARC genes in top anti-correlated genes to each miRNA of interest. Supplementary table 4. Top 20 Gene Ontologies (GO) enriched in genes having validated interactions with miRNA. Supplementary table 5. Cancer Gene Census information for genes significantly anti-correlated with miRNAs of interest.