Potential preventive efffects of time-restricted eating on cancer

Intermittent fasting is a novel dietary intervention that has been demonstrated to improve the efficacy of cancer therapy and reduce com-plications.Time-restricted eating is a specific form of intermittent fasting.It usually restricts only the daily eating window and not the amount of calories consumed.In addition to providing a means for weight management and improving metabolism like other intermittent fasting methods,time-restricted eating also synchronizes circadian rhythms and affects autophagy levels,which has potential antiaging effects.Some studies have shown that time-restricted eating can prevent tumorigenesis and slow tumor progression.Moreover,be-cause of its simplicity and mild adverse effects,time-restricted eating is safe and has a high rate of compliance.It may be used an ad-juvant therapy and may be part of a healthy lifestyle suitable for long term by cancer patients or those at high risk of developing specific cancers.This article expounds on the potential impact of time-restricted eating on the prevention and treatment of cancer,as well as the potential mechanism(s)of action.There are 3 main aspects considered to be impacted by time-restricted eating:improving obesity and metabolic disorders,synchronizing the circadian rhythm,and upregulating autophagy.We herein present the current research progress related to the effects of time-restricted eating on malignant tumors.The purpose of this review is to provide a theoretical basis and di-rection for future research to explore the potential of time-restricted eating as a nutritional intervention to prevent the occurrence of can-cer and as a treatment or adjuvant therapy for cancer.We believe that this approach may be conducive to improving the nutritional sta-tus of cancer patients and improving their prognosis and quality of life.