Integrating MWCNTs-doped MXene with multi-spiral-channel architecture enables field effect transistor biosensor capable of ultrasensitive determination of methotrexate
Arabian Journal of Chemistry(2023)
摘要
Previous breakthroughs in biosensor diagnostics stem from engineering and nanocomposites. Accurately detecting low-abundance compounds such as methotrexate in complex biospecimens (e.g. serum) is an important clinical challenge. To address this issue, a MWCNTs-doped MXene-based multi-spiral-channel field-effect transistor (MMSFETs) biosensor was constructed for ultrasensitive quantification of methotrexate. Our integrated biosensor exhibited following merits: a) The synergetic performance of MXene and MWCNTs for enhanced transconductance (0.63 mS) and detection capability (methotrexate, linear range of 0.001–100 μM and LOD down to 0.352 nM); b) Favorable selectivity, stability (one month), reproducibility (RSD = 0.99%, n = 7) for biosensing of methotrexate; c) Acceptable clinical performances on comparisons of MMFETs against commercial Abbott automatic immunoluminescence instrument (ARCHITECT I1000): favorable linearity and correlation coefficient (YMMSFETs = 1.4305 × Xtargeted concentration + 4.3791 with R2 = 0.949), significant p value (7.68E-12 < 0.001) and diagnosis capability of AUC (0.9907). Those advantages are anticipated to pave an avenue to design of the FETs-based biosensor towards the point-of-care diagnostics applications.
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关键词
MWCNTs-doped MXene,Multi-spiral,Field effect transistor,Biosensor,Methotrexate
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