DRUM-PD/HD: The Impact of a Pilot Group Drum-Based Music Therapy Intervention on Quality of Life and Motor Symptoms in Parkinson Disease and Huntington Disease

Rhythm-based therapeutic interventions have widely been used in patients with neurologic disorders to address motor and quality of life outcomes. Although group drumming has been explored in several pilot studies of patients with Parkinson disease (PD) and Huntington disease (HD), caregiver burden and their quality-of-life outcomes have received less attention. Therefore, we aimed to evaluate the impact of group drumming on quality of life and motor symptoms in PD and HD patients as well as their caregivers. A total of 17 participants (PD = 6, caregivers of PD = 6, HD = 3, caregivers of HD = 2) attended the 60-minute drum-based group music therapy intervention twice a week for 12 weeks. Participants were assigned to two drumming intervention groups based on their diagnosis:1) patients diagnosed with PD and their study partners, 2) patients diagnosed with HD and their study partners. In group drumming sessions, both patients and caregiver participants utilized a variety of percussion instruments based on their personal preferences or physical abilities to facilitate movement skills and group cohesion. They were asked to complete questionnaires about quality of life and motor functioning at baseline, 6 weeks, 12 weeks, and 18 weeks (6 weeks post-intervention completion). Caregivers burden scores were also collected at these time points. Furthermore, all participants completed simple exit interview questionnaires in their follow-up visit. The PD participants and their caregivers showed an opposite trend in social role satisfaction. From baseline to 6 weeks, there were significant differences in social role satisfaction between PD participants and PD caregivers where PD participants reported a decrease in social satisfaction (Mean = -2.30, Standard Deviation = 1.64) while PD caregivers experienced an increase (M = 3.80, SD = 3.08), p = .02. In contrast, a different pattern was shown from 12 weeks to 18 weeks, where PD participants showed an increase in social satisfaction (M = 2.53, SD = 1.29), while PD caregivers demonstrated a decrease in social satisfaction (M = -2.10, SD = 3.35), p =.03. Drumming in a group setting may serve as an effective tool to enhance movement and promote social cohesion through rhythmic auditory-motor entrainment, thereby supporting quality of life in PD; further studies in HD are indicated as well. ### Competing Interest Statement The authors have declared no competing interest. ### Clinical Trial NCT05157074 ### Funding Statement No external funding was received for this study. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study protocol was approved by the Institutional Review Board at the Johns Hopkins Medical Institutions (Baltimore, MD; IRB# IRB00147450) and registered at ClinicalTrials.gov (NCT# [NCT05157074][1]). I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable. Yes All data produced in the present study are available upon reasonable request to the authors [1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT05157074&atom=%2Fmedrxiv%2Fearly%2F2023%2F05%2F05%2F2023.05.04.23289514.atom