A Comparison of the Pharmacokinetics and Safety of Dapagliflozin Formate, an Ester Prodrug of Dapagliflozin, to Dapagliflozin Propanediol Monohydrate in Healthy Subjects

Hyun Chul Kim, Sangmi Lee, Siyoung Sung, Eunjin Kim,In-Jin Jang,Jae-Yong Chung

Drug Design, Development and Therapy（2023）

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摘要

The rapid conversion of DAP-FOR into dapagliflozin led to the extremely low exposure of DAP-FOR and comparable PK profiles of dapagliflozin between DAP-FOR and DAP-PDH. The safety profiles were also similar between the two drugs. These results suggest that DAP-FOR can be used as an alternative to DAP-PDH.

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clinical trial,dapagliflozin,pharmacokinetics,phase I,prodrugs

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