Early Repolarization Pattern and Suicidal Risks: A Single Center Case-Control Study

Background Early repolarization pattern was reported to be associated with mental illness. However, its role in patients with the suicidal risks remains unclear. Objective The aim of this study is to examine the frequency of Early repolarization pattern in patients with the suicidal risks compared with the age matched medical checkups. Method A retrospective analysis of 27 patients with a history of suicide risks, including suicide attempt and nonsuicidal self-injury, and a family history of suicide. The presence of early repolarization pattern was compared in patients with suicidal risks and controls. Social and psychological factors were also compared among the patients with suicidal risks with or without Early repolarization pattern. Result Comparing the controls, Early repolarization pattern was significantly observed in the patients (14 patients: 52%, 7 controls: 9%, P<0.001). After logistic regression including the other clinical findings among the patients and controls, the presence of Early repolarization pattern was associated with the patients with the suicidal risks (p < 0.001). In the patients with suicide, there were no difference between the clinical factors compared with or without Early repolarization pattern. Conclusion There could be association between Early repolarization pattern and the patients with the suicidal risks. Further studies are needed to confirm the association between suicidal risks and Early repolarization pattern. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement None ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: This study has been implemented with the approval of our ethics committee (approved No. 30-152). All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes N/A