Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system
bioRxiv (Cold Spring Harbor Laboratory)(2023)
摘要
We provide evidence that stroke-induced gut breakdown results in bacteria translocation to the ischaemic mouse brain. Inhibition of sympathetic tone reduced bacterial load in the post-stroke brain and reduced functional deficits without altering cerebral apoptosis, neuroinflammation or infarct volume. These findings indicate that the activation of the sympathetic nervous system after stroke promotes gut-derived bacteria to enter to the brain, and this process worsens motor function in mice.
### Competing Interest Statement
The authors have declared no competing interest.
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关键词
ischaemic stroke,sympathetic nervous system,bacteria,gut
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