The intersection between senescence-mediated vascular dysfunction and cognitive impairment in female mice.

Editorial FocusConsidering Sex as a Biological Variable in Cardiovascular ResearchThe intersection between senescence-mediated vascular dysfunction and cognitive impairment in female miceAnil Sakamuri and Bernard Ojwang OgolaAnil SakamuriVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, United States and Bernard Ojwang OgolaVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, United StatesDepartment of Medicine, Medical College of Georgia at Augusta University, Augusta, Georgia, United StatesPublished Online:06 Mar 2023https://doi.org/10.1152/ajpheart.00076.2023This is the final version - click for previous versionMoreSectionsFull TextPDF (461 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations REFERENCES1. Ogola BO, Abshire CM, Visniauskas B, Kiley JX, Horton AC, Clark-Patterson GL, Kilanowski-Doroh I, Diaz Z, Bicego AN, McNally AB, Zimmerman MA, Groban L, Trask AJ, Miller KS, Lindsey SH. Sex differences in vascular aging and impact of GPER deletion. Am J Physiol Heart Circ Physiol 323: H336–H349, 2022. doi:10.1152/ajpheart.00238.2022. Link | ISI | Google Scholar2. Jiménez-Altayó F, Onetti Y, Heras M, Dantas AP, Vila E. Western-style diet modulates contractile responses to phenylephrine differently in mesenteric arteries from senescence-accelerated prone (SAMP8) and resistant (SAMR1) mice. Age (Dordr) 35: 1219–1234, 2013. doi:10.1007/s11357-012-9450-6. Crossref | PubMed | Google Scholar3. Rossman MJ, Kaplon RE, Hill SD, McNamara MN, Santos-Parker JR, Pierce GL, Seals DR, Donato AJ. Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function. Am J Physiol Heart Circ Physiol 313: H890–H895, 2017. doi:10.1152/ajpheart.00416.2017. Link | ISI | Google Scholar4. Johnson MD, Wray A. Alpha 1 adrenergic receptor function in senescent Fischer 344 rat aorta. Life Sci 46: 359–366, 1990. doi:10.1016/0024-3205(90)90015-j. Crossref | PubMed | ISI | Google Scholar5. Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. eNOS activity is reduced in senescent human endothelial cells: preservation by hTERT immortalization. Circ Res 89: 793–798, 2001. doi:10.1161/hh2101.098443. Crossref | PubMed | ISI | Google Scholar6. Imanishi T, Hano T, Nishio I. Estrogen reduces endothelial progenitor cell senescence through augmentation of telomerase activity. J Hypertens 23: 1699–1706, 2005. doi:10.1097/01.hjh.0000176788.12376.20. Crossref | PubMed | ISI | Google Scholar7. Costa TJ, Barros PR, Duarte DA, Silva-Neto JA, Hott SC, Santos-Silva T, Costa-Neto CM, Gomes FV, Akamine EH, McCarthy CG, Jimenez-Altayo F, Dantas AP, Tostes RC. Carotid dysfunction in senescent female mice is mediated by increased α1A-adrenoceptor activity and COX-derived vasoconstrictor prostanoids. Am J Physiol Heart Circ Physiol 324: TBA, 2023. doi:10.1152/ajpheart.00495.2022. Link | Google Scholar8. Kehmeier MN, Bedell BR, Cullen AE, Khurana A, D’Amico HJ, Henson GD, Walker AE. In vivo arterial stiffness, but not isolated artery endothelial function, varies with the mouse estrous cycle. Am J Physiol Heart Circ Physiol 323: H1057–H1067, 2022. doi:10.1152/ajpheart.00369.2022.Link | ISI | Google Scholar9. Blackwell JA, Silva JF, Louis EM, Savu A, Largent-Milnes TM, Brooks HL, Pires PW. Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice. Am J Physiol Heart Circ Physiol 323: H845–H860, 2022. doi:10.1152/ajpheart.00276.2022. Link | ISI | Google Scholar10. Arnold AP, Xu J, Grisham W, Chen X, Kim YH, Itoh Y. Minireview: sex chromosomes and brain sexual differentiation. Endocrinology 145: 1057–1062, 2004. doi:10.1210/en.2003-1491. Crossref | PubMed | ISI | Google Scholar Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Related ArticlesCarotid dysfunction in senescent female mice is mediated by increased α1A‐adrenoceptor activity and COX-derived vasoconstrictor prostanoids 06 Mar 2023American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 324Issue 4April 2023Pages H411-H413 Crossmark Copyright & PermissionsCopyright © 2023 the American Physiological Society.https://doi.org/10.1152/ajpheart.00076.2023PubMed36800510History Received 10 February 2023 Accepted 15 February 2023 Published online 6 March 2023 Published in print 1 April 2023 Keywordsadrenergic receptorsagingsenescencesex differencevascular function Metrics