An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of methotrexate in human serum and plasma.

Anett Engel, Lena Ruhe,Neeraj Singh, Jo Anne Wright,Franziska Liesch,Friederike Bauland, Annika I Ostermann, Tamara Sumalowitsch, Vincent J T Schweinsberg,Andrea Geistanger,Johannes Kolja Hegel,Christian Geletneky,Judith Taibon

Clinical chemistry and laboratory medicine（2023）

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摘要

This ID-LC-MS/MS-based approach provides a candidate RMP for methotrexate quantification. Traceability of methotrexate standard and the LC-MS/MS platform were assured by qNMR assessment and extensive method validation.

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关键词

SI units,isotope dilution LC-MS/MS,methotrexate,qNMR,reference measurement procedure,traceability

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