The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells.

Nadine Bachtler,Sandra Torres,Cristina Ortiz,Robert Schierwagen,Olaf Tyc,Christoph Hieber,Marie-Luise Berres,Caroline Meier,Nico Kraus,Stefan Zeuzem,Bart Nijmeijer,Sebas Pronk,Jonel Trebicka,Sabine Klein

PloS one（2023）

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摘要

ROCK inhibition by the tested compounds decreased contraction but increased migration. Y-33075 proved more potent than Y27632 in the inhibition of contraction of HSCs and should be further evaluated in chronic liver disease.

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关键词

hepatic stellate cells,non-selective,rho-kinase

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