Neurovascular hypoxia after mild traumatic brain injury in juvenile mice correlates with heart-brain dysfunctions in adulthood.

Katherine Leyba,Nitchawat Paiyabhroma,John P Salvas,Frederick W Damen, Alicia Janvier,Emma Zub, Corinne Bernis,Richard Rouland,Christophe J Dubois,Jerome Badaut,Sylvain Richard,Nicola Marchi,Craig J Goergen,Pierre Sicard

Acta physiologica (Oxford, England)（2023）

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摘要

Experimental juvenile mTBI induces time-dependent cardiac dysfunction that corresponds to the initial neurovascular sO dip and is associated with long-term behavioral modifications. These imaging biomarkers of the heart-brain axis could be applied to improve clinical pediatric mTBI management.

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关键词

4D ultrasound,diastolic dysfunction,heart-brain axis,photoacoustic imaging,traumatic brain injury

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