In-Hospital Outcomes of Patients With Obstructive Sleep Apnea Undergoing Atrial Septal Defect Repair

Introduction: There is emerging new evidence of an association of atrial septal defects (ASD) with hypoxic conditions such as obstructive sleep apnea (OSA). In this study, we determined in-hospital outcomes of patients with OSA undergoing percutaneous ASD repair (ASDR). Methods: The National Inpatient Sample Database was queried from 2011-2019 for relevant ICD-9 and -10 procedural and diagnostic codes. Baseline characteristics and in-hospital outcomes were compared in patients with and without a history of OSA with a primary diagnosis of ASD who underwent ASDR (Surgical or percutaneous) on the index admission. Logistic-regression was performed to adjust for pre-specified co-variable for different outcomes. p-value was considered significant when <0.001. Results: We identified a weighted sample of 132,221 patients (≥18 years old) with a primary diagnosis of ASD, out of whom 10.9% (14,457) had ASDR. Of patients who underwent ASDR, 11.2% (1,615) carried a diagnosis of OSA. Baseline characteristics are shown in Table 1. There was no statistically significant difference in all-cause mortality between patients who underwent ASDR, with and without OSA (2.7% vs 2.7%). After adjusting for potential confounders, there was no statistical difference between both groups’ in-hospital outcomes such as total cost, length of stay, acute renal failure, stroke rate, vascular or pericardial complications. Conclusions: Although patients with OSA who underwent ASD repair have higher co-morbidities, they were not at higher risk for inpatient complications post-procedure and there was no difference in mortality noted. Prospective studies are needed to further investigate the effect of ASDR in OSA patients.