Biodegradable coated stent in the treatment of coronary heart disease in the elderly

Hui Fan,Jun Ma, Chao Li, Geli Xing, Yi Han

Applied Nanoscience(2022)

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摘要
With the improvement of people’s life and the development of aging society, the incidence of coronary heart disease is increasing. The purpose of this paper is to study the effect of biodegradable coated stent in the treatment of elderly patients with coronary heart disease. The method of combining morphology with physicochemical modification is put forward, that is, the micro morphology of material surface and plasma SiOx:H Combined with the advantages of nano coating and two surface modification technologies, the biocompatibility of the materials can be improved and the adhesion of endothelial cells can be promoted. Our goal is to accelerate the process of endothelialization and ultimately reduce ISR. The 1-year follow-up results of this study were summarized. The experimental results showed that the incidence of secondary end points, poce, nacce and major bleeding (barc3.5 bleeding) were similar (19.8% vs.20.4%, P = 0.74, 25.6% vs.27.1%, P = 0.49 and 1.9% vs.1.2%, P = 0.24, respectively). Plasma Siox:H There was no significant difference in the incidence of ST (1.3% vs.0.5%, P = 0.09) between dapt group and dapt group at 6 months and 12 months postoperatively. Plasma application in PCI patients Siox:H The efficacy and safety of nano-coated stent after 1 year is not inferior to that of dp-ses, and plasma Siox:H The long-term prognosis of 6-month dapt is consistent with that of 12-month dapt.
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关键词
Coronary heart disease, Biodegradable stent, Coated stent, Nanometer material
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