EP108/#805 Racial disparities in endometrial cancer patients at a single academic institution

Objectives

Historically, black patients with endometrial cancer (EC) have worse survival than non-black patients. Obesity has been associated with poor survival in many cancers, though a relationship between race/obesity and survival is not well understood. We sought to investigate the relationship between these factors and survival in EC patients.

Methods

EC patients between 2007–2021 were included. Demographic/death information was collected from the EMR and public records. Effect of BMI/race on overall survival was analyzed using Kaplan-Meier survival methods and Cox hazard ratios.

Results

1042 women were included. Black women had higher death rates than non-black women (17.4% v. 11.3%, p<0.01) and decreased five-year cancer-specific survival (68.6% vs 83.4%, p=<0.001). Black women were more likely to be morbidly obese (35.7% v 23.5%, p<0.001), but there was no difference in presentation of obese/overweight/normal BMI patients (HR=0.66, 95% CI:0.35–1.24; HR=0.61, 95% CI:0.36–1.02; HR=065, 95% CI:0.39–1.10). There was no difference in risk of EC death in morbidly obese/obese/overweight patients compared to normal BMI patients (95% CI: 0.35–1.24; 0.36–1.20; 0.39–1.10). There was no difference in age at diagnosis between black and non-black women, although age at diagnosis increased risk of death in populations 60–69, 70–79, and >80 years compared to <49 years (HR=8.76, 95% CI:1.16–66.00; HR=10.51, 95% CI:1.35–81.78; and HR=22.00, 95% CI:2.75–176.14).

Conclusions

Black women at our institution had higher EC-specific mortality than non-black women. This disparity cannot be contributed to differences in BMI or age; investigation into other contributing factors is warranted to diminish disparities and improve survival of black women with EC.