Matrix mechanophysical factor: pore size governs the cell behavior in cancer

Cancer tissues are a heterogeneously multifaceted assembly. Understanding the relationship of tumors with their microenvironment is also required to understand the tumor progression and metastasis better. Like tumors, the tumor microenvironment (TME) is heterogeneous, offering numerous mechanobiological, mechanochemical, and mechanophysical cues. Biomaterials impersonating extracellular matrix (ECM) properties must provide the mechanical cues cells get from their 3D extracellular environment. Pore size is one imperative yet less studied ECM factor implicated in the invasion and migration of the tumor. Several techniques are used to control the pore size of biomaterials constructed for a distinct tissue. Electrospinning is one of the most steadfast techniques for producing scaffolds with the preferred pore size. A comprehensive interpretation of ECM pore size would contribute toward a better understanding of the reciprocal interaction between pore size and tumor progression and can be used as a promising target for cancer treatments. In this review, we abridged the knowledge pertaining to (1) ECM and pore size, (2) the importance of pore size and its interplay with cancer, and (3) current advancement in the field of biomaterials to study pore size. Overall, this review will cover the effect of pore size on tumor cell behavior concerning electrospinning.