C-H Fluoromethoxylation of Arenes by Photoredox Catalysis.
Angewandte Chemie (International ed. in English)(2023)
摘要
Redox-active N-(fluoromethoxy)benzotriazoles were made accessible from fluoroacetic acid and hydroxybenzotriazoles via electrodecarboxylative coupling. After alkylation, they become effective monofluoromethoxylation reagents, enabling the photocatalytic C-H functionalization of arenes. Thus, irradiation of 1-(OCH F)-3-Me-6-(CF )benzotriazolium triflate with blue LED light in the presence of [Ru(bpy) (PF ) ] promotes the synthesis of diversely functionalized aryl monofluoromethyl ethers. This method allows the late-stage functionalization of biologically relevant structures without relying on ecologically problematic halofluorocarbons.
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关键词
Electrosynthesis,Fluorine,Monofluoromethyl,Photochemistry,Radical Reactions
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