Comment on "associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan" clinical nutrition 2022

We congratulate Sanmei et al. [ [1] Chen S. MIki T. Fukunaga A. Eguchi M. Kochi T. Nanri A. et al. Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: a prospective study in Japan. Clin Nutr. 2022; 41: 1828-1833https://doi.org/10.1016/j.clnu.2022.06.039 Abstract Full Text Full Text PDF Scopus (1) Google Scholar ] for the elaboration of this exceptional study, which investigated the prospective associations between serum amino acids and insulin resistance in eutrophic, overweight or obese Japanese adults. First, the fact that the present study investigated the differences in the associations between serum amino acids and insulin resistance in overweight/obese individuals caught our attention, since this clinical feature is common in patients with Type 2 Diabetes (DM2). Evidence shows that the prevalence of overweight and obesity has increased considerably in recent decades, becoming a “silent pandemic”. These processes are often associated with dyslipidemia and DM2, with cardiovascular diseases (CVD) as the main outcome. With the advancement of science, the understanding of the pathophysiological mechanisms of obesity became clear, in this sense, several studies were carried out with the objective of identifying its contribution in the development of this disease, as is the case of this study [ 2 Lebovitz H.E. Insulin resistance: definition and consequences. Exp Clin Endocrinol Diabetes. 2001; 109: S135-S148 Crossref PubMed Scopus (293) Google Scholar , 3 Melmer A. Kempf P. Laimer M. The role of physical exercise in obesity and Diabetes. Praxis (Bern 1994. 2018; 107: 971-976 Crossref PubMed Scopus (10) Google Scholar , 4 Yazıcı D. Sezer H. Insulin resistance, obesity and lipotoxicity. Adv Exp Med Biol. 2017; 960: 277-304 Crossref PubMed Scopus (204) Google Scholar ]. Reply ‒ letter to the editor: Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in JapanClinical NutritionPreviewIn Reply We acknowledge the comments of Dr. Felipe J Aidar and colleagues [1] to our article on the prospective associations between circulating amino acids and insulin resistance among Japanese working adults with and without overweight or obesity [2]. The authors raised concerns about the wide age range of our study population (22–71 years) and the potential heterogeneity in the amino acid － insulin resistance associations between younger and older people. We should first note that 96% of the participants were aged 30–64 years and confirmed that the exclusion of participants outside of this range did not materially change the results. Full-Text PDF