In Vitro Anti-Inflammatory Activity of Green Synthesized Silver Nanoparticles and Leaf Methanolic Extract of Solanum khasianum Clarke

Inflammation leads to several deleterious effects in the body. The main aim of this study was to evaluate the in vitro anti-inflammatory activity of the green synthesized silver nanoparticles and methanolic leaf extract of Solanum khasianum by Human Red Blood Cell membrane stabilization method. The inhibition of membrane lysis, which is influenced by the hypotonicity of the medium, is taken into consideration to evaluate the anti-inflammatory activity. The biosynthesis of silver nanoparticles was achieved using aqueous leaf extract with 1 mM silver nitrate. The synthesized silver nanoparticles were confirmed by UV–Visible Spectrophotometer with a peak of 440 nm. The green synthesized silver nanoparticles showed significant anti-inflammatory activity than the leaf methanolic extract of S. khasianum. The present study will be necessary for the utilization of biosynthesized silver nanoparticles as the potential anti-inflammatory compound in anti-inflammatory drugs.