Nanotechnology reinforced neutrophil-based therapeutic strategies for inflammatory diseases therapy

Nano Today(2022)

引用 5|浏览7
暂无评分
摘要
Misguided attack of immune systems on self-tissue or multifactorial uncontrolled inflammation is capable of causing inflammatory diseases. Neutrophils play a critical role in the initiation of inflammation and pathophysiological progression, and the pathological context can influence the biology of neutrophils. Moreover, they usually respond faster than other immune cells to pathological variation. Recently, due to their immunomodulation capability and intrinsic tropism to inflammatory sites, neutrophil-based therapeutic strategies, including neutrophil manipulation and development of neutrophil-based delivery systems, are emerging as a promising solution for the treatment of inflammation-related diseases. However, obstacles in neutrophil manipulation using small molecules or antibodies (e.g., lack of targeting ability to the inflammatory site, low bioavailability, and fast clearance) and the concerns about developing neutrophil-based delivery systems (e.g., stability of biopharmaceuticals, activity maintenance, and cargo loading efficiency) hindered the therapeutic outcomes of neutrophil-based therapeutic strategies. Nanotechnology, which has offered multiple resolutions for disease treatment, can be utilized to reinforce neutrophil-based therapeutic strategies. In order to afford a comprehensive overview of the state-of-the-art progress of this emerging field, the biology of neutrophils and their function in a certain inflammatory context is briefly introduced. Then the current research progresses about nanomaterials augmented efficient neutrophils manipulation and developing neutrophil-based carriers utilizing nanotechnology for inflammation-targeted treatment are illustrated with specific research examples. Finally, perspectives in light of the current challenges and future opportunities in this field are discussed.
更多
查看译文
关键词
Nanotechnology,Neutrophil manipulation,Neutrophil-based carrier,Extracellular vesicles,Membrane-derived biomimetic delivery system,Inflammatory disease
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要