A De-novo Case of Philadelphia Chromosome Positive B-Cell Acute Lymphoblastic Leukaemia in Elderly with Past History of Endometrial Carcinoma

Introduction: Philadelphia chromosome is well-known chromosomal abnormality in Chronic Myeloid Leukaemia (CML). However, B-acute lymphoblastic leukemia (B-ALL) with Philadelphia-positive (Ph′+) is a neoplasm of lymphoblast committed to the B-cell lineage, occurs in about 20 % to 30 % of all cases in adults. The incidence increases with age, up to 50 % of ALL diagnosed in individual’s ≥50 years old. The clinical presentation of B-ALL Ph′+ is similar to B-ALL but is more common in adults than in children. Case Report: A 64 year-old female patient presented to Medicine OPD with complaints of fever, weakness and uneasiness, along with old history of endometrial carcinoma. She was further investigated and diagnosed as De-novo case of B-precursor ALL with positive BCR-ABL fusion gene as no chemotherapy was given for previously reported malignancy. Conclusion: Here, we like to emphasize that overlapping symptoms may lead to delay in diagnosis. Hence, clinician should always investigate the patient thoroughly, in order to diagnose the patient on time. So that, treatment can be started as early as possible to avoid fatal outcomes in Ph′ Chromosome positive B cell ALL, as it has worst prognosis.