Reply to "Neuropsychiatric symptoms in community-dwelling older Brazilians with mild cognitive impairment and dementia".

We thank the readers for their interest in our manuscript. We agree that Nunes et al.,1 found elevations in mild cognitive impairment on 7 of 12 Neuropsychiatric Inventory items. The study by Wilson et al.,2 was built on the prior literature including Nunes et al.,2 by deriving composite measures of behavioral and psychological symptoms from the Neuropsychiatric Inventory and using these as outcomes instead of individual Neuropsychiatric Inventory items, thereby likely minimizing measurement error. With these composite measures, we were able to show that mild cognitive impairment is characterized by a global (rather than a selective) elevation in neuropsychiatric symptoms. Thus, our paper differs from and nicely complements that of Nunes et al. Separately, we apologize for not specifically acknowledging the sources of cases for the study. We requested that the editor add an acknowledgment or correction to the paper, which states “The authors thank the thousands of Brazilian informants who participated in this study. We thank the staff of the Pathology, Alzheimer's and Related Dementias Study (PARDoS) and the Rush Alzheimer's Disease Center for their support. We thank the Núcleo de Estudos Pesquisa e Assessoria à Saúde (NEPAS), and the Instituto de Assistência Médica ao Servidor Publico Estadual (IAMSPE), where the project is now located and active. We also thank the Fundação Faculdade de Medicina (FFM), the São Paulo Autopsy Service (SVOC) at the University of São Paulo (USP), and its Medical School (FMUSP), where the project was conducted until September 5, 2019.” All data collected for our study were collected prospectively by staff paid solely with funds from Rush University Medical Center, and from ongoing National Institutes of Health (NIH) grant R01AG54058 to Dr Bennett at Rush University Medical Center, with a subcontract to Dr Farfel via FFM for the University of Sao Paulo until September 5, 2019, and via NEPAS for IAMSPE, after the study was terminated in FMUSP. The Brazilian institutions also received the standard foreign country indirect rate and used some of those funds to provide space and infrastructure for the work. The authors thank the informants and study staff in Brazil and the United States. This work was supported by the National Institute on Aging (R01AG54058) and Rush University Medical Center. In the past 36 months, all authors received funding from the National Institutes of Health. AC received consulting fees from Communication Bridge (funding to AC). DB received consulting fees from Origent, Inc (SBIR) (funding to DB) and an honorarium from Academia (funding to DB), and he participates on Advisory Boards for AbbVie and B4X, Inc (no payments yet). No authors have any conflicts to declare. Author disclosures are available in the supporting information. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.