Will Choice of Treatment Influence TIR in T2D with Diabetic Complications?

Though TIR is a predictive marker of diabetic complications, there is paucity of data evaluating the association of TIR with therapeutic regimens. We investigated the association of CGM-derived metrics, with presence of complications and therapeutic regimen in T2D. We analyzed AGP of T2D who underwent 14-day p-CGM between 2015 and 2021. Clinical parameters were extracted from EMR. Data of 1218 T2D (baseline age=53.14±15.03 yrs; 69.2% male, avg. duration of diabetes: 14.44±9.48 yrs) on different therapeutic regimen (OHAs±insulin; namely basal only, biphasic, basal plus, basal bolus regimen) were analyzed. A regression model was run with % TIR as dependent variable and age, duration, insulin regimen, complications, and BMI as independent variables. Spearman’s correlation coefficient was calculated between lab A1C and eA1c. On analysis, age was found to have a statistically significant relation with TIR. A moderate correlation (0.60) between A1C and eA1C was observed. 68.4% achieved a target TIR of >70% in T2D without complications. 69.5% with CAD/CKD achieved target TIR of >50%. Among the different therapeutic regimens analyzed, use of analogue basal-bolus regimen was associated with statistically significant (p<0.05) TIR target of >50% and TBR<1% in T2D with CAD/CKD (Figure 1) . In T2D with vascular complications, analogue basal bolus regimen could be a superior choice in reaching optimal TIR with insignificant time below range. Disclosure J.Kesavadev: None. B.D.Saboo: None. A.Shankar: None. G.Krishnan: None. G.Sanal: None. A.Basanth: None. S.Jothydev: None.