IDF21-0459 Prevalence, clinical profile and follow up of asymptomatic bacteriuria (ASB) in patients with Type 2 Diabetes

Background: Patients with diabetes mellitus (DM) have asymptomatic bacteriuria (ASB) more often than those without DM. It is unclear, how the natural history of ASB in Type 2 Diabetes (T2D) patients behaves. Aim: The present study intended to study the prevalence, clinical profile, complications and follow up of ASB in T2D patients. Method: This was a cross sectional prospective study done on 400 T2D patients with no symptoms of urinary tract infection (UTI) and 200 healthy controls. Various clinical, biochemical parameters and urine examination and culture were monitored. All the ASB T2D patients were followed for 6 months with respect to number of UTIs, glycemic control and renal parameters. Results: The prevalence of ASB at baseline was significantly higher in T2D (17.5%) as compared to controls (10%). E. coli was the most common organism. T2D ASB patients were mostly postmenopausal females, uncontrolled diabetes and long duration of diabetes. Presence of diabetic nephropathy, HTN, CKD, UTI in previous year, uncontrolled BP, obesity, lower eGFR, proteinuria and glycosuria increased the risk of ASB in T2D patients. Of the 64 T2D ASB patients followed till 6 months, 14 (21.8%) developed symptomatic UTI. Postmenopausal state, uncontrolled diabetes, longer diabetes duration, presence of diabetic nephropathy and glycosuria significantly increased the risk of development of symptomatic UTI. ASB in T2D patients who develop UTI leads to worsening of glycemic control with no effect on renal function on follow up. Discussion: ASB in T2D patients can be consequences of or lead to uncontrolled glycemia. ASB patients who develop UTI leads to worsening of glycemic control but there was no effect on renal function on follow up.