Abstract 10143: Rising Burden Of Cardiovascular Disease Risk Factors And Acute Cardiac Events In Young Adults With Comorbid Depression: A Comparison Of Two Nationwide US Cohorts Hospitalized 10-years Apart

Background: Previous literature suggests an association between depression and cardiovascular diseases. Due to the paucity of data in the young, we aimed to investigate the prevalence of cardiovascular disease (CVD) risk factors and associated major adverse cardiac and cerebrovascular events (MACCE) in young adults hospitalized with comorbid depression a decade apart. Methods: We conducted a retrospective analysis of the National Inpatient Sample database for the years 2007 and 2017. Young adults (18-44 years) hospitalized with comorbid depression were identified using ICD-9 CM/ICD-10 codes. Frequency and trends in demographics and comorbidities including cardiovascular disease risk factors and MACCE were compared between the 2017 vs. 2007 cohort. Results: A total of 1,274,118 (median age 34 [27-40] yrs, 68.7% females) young admissions were recorded with comorbid depression. When the 2007 cohort was compared with the 2017 cohort, a rising trend in depression was observed (5.5% vs. 8.2%) (p <0.001). The 2017 cohort of young adults with depression more often consisted of male, non-white patients . Burden of CVD risk factors (hypertension, diabetes with chronic complications, smoking and obesity) was also greater in the 2017 cohort.. Although the all-cause mortality remained comparable (0.3%) in both cohorts, there was a significantly higher rate and risk of MACCE including acute myocardial infarction (aOR 1.18, 95%CI:1.10-1.26), atrial fibrillation/ flutter (aOR 1.47, 95%CI:1.40-1.54) and stroke (aOR 1.33, 95%CI: 1.26-1.40) (p <0.001) in the 2017 cohort (Table 1) . Conclusion: This nationwide study reveals alarmingly increased prevalence of CVD risk factors and increase in the rate and risk of MACCE in two cohorts of young adults with comorbid depression studied a decade apart. Burden of mental disorders in young adults has been rising in the last decade and warrants extra vigilance by clinicians to curtail CVD risk and improve MACE-associated outcomes.