Abstract 11293: Trends in Pulmonary Embolism Mortality Rates Among Racial Minorities in the United States, 1999-2019

Introduction: Acute pulmonary embolism (PE) is a major cause of mortality in the United States (US). Recent reports indicate that PE-related mortality rates have increased among all Americans, non-Hispanic White Americans, and non-Hispanic Black Americans in the last decade. Here, we report PE-related mortality trends in the US among non-Hispanic American Indian or Alaska Natives (NHAIAN), non-Hispanic Asian or Pacific Islanders (NHAPI), and Hispanic and/or Latino Americans (HL) between 1999 and 2019. Methods: Death certificate data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database were examined to determine all-cause PE mortality trends from 1999 to 2019 among adults older than twenty-five years old. The annual mortality rates were calculated per 100,000 population and age-adjusted based on the US population in the year 2000. The annual percentage change (APC) with corresponding 95% confidence intervals (CIs) were calculated to determine trends. Results: While overall AAMR decreased from 14.7 to 13.5 (APC -0.4 [95% CI -0.6 to -0.2) between 1999 and 2013, overall AAMR increased from 13.5 to 14.5 (APC 1.3 [95% CI 0.7 to 1.9]) between 2013 and 2019. NHAIAN AAMR increased from 9.68 to 12.09 (APC 1.2 [95% CI 0.5 to 1.9]) between 1999 and 2019. Among NHAPI, AAMR fluctuations prior to 2016 were not statistically significant. NHAPI AAMR increased from 3.81 to 4.58 (APC 6.2 [95% CI 0.5-12.3]) between 2016 and 2019. Among HL, AAMR decreased from 8.91 to 8.19 (APC -0.5 [95% CI -0.8 to -0.1]) between 1999 and 2019. Conclusions: Despite significant improvements in PE risk stratification and clinical management, PE related mortality increased significantly among NHAIAN between 1999 and 2019 and NHAPI between 2016 and 2019. The only racial cohort with a statistically significant reduction in AAMR during the entire study period was HL.