Dual Reactive Oxygen Species Generator Independent of Light and Oxygen for Tumor Imaging and Catalytic Therapy

Currently, reactive oxygen species (ROS) generation primarily depends upon light and O-2, which hampers its further biomedical application. Here, we report that amanganese(III) salen-based complex (MnS) can continuously catalyze overexpressed hydrogen peroxide (H2O2) in the tumor microenvironment to O-1(2), while the nanocarrier (MIL-100) as a Fenton reagent can convert H2O2 to hydroxyl radicals (center dot OH) through the Fenton reaction, inducing noticeable intracellular DNA strand scission and lipid peroxidation to provoke tumor cell apoptosis without the involvement of light and O-2. Moreover, MIL-100 depleted the antioxidant glutathione, further amplifying intracellular oxidative pressure, which in turn led to the self-degradation of MIL-100, suggesting the long-term biosafety of the nanoplatform. Owing to the excellent magnetic resonance imaging performance ofMnS, the diagnosis and specific treatment of tumors were eventually achieved. This work provides a novel approach for the realization of effective tumor catalytic therapy independent of light and O-2 and a promising reference for the development of a wide range of catalytic therapeutic agents. [GRAPHICS] .