The top-10 research priorities in psoriatic arthritis: a James Lind Alliance Priority Setting Partnership

Objectives: To identify and prioritise the top 10 research questions for psoriatic arthritis (PsA). Methods: The British Psoriatic Arthritis Consortium (BritPACT) formed a Priority Setting Partnership (PSP) comprising of people living with PsA, carers and clinicians, supported by the James Lind Alliance (JLA). This PSP followed the established three-stage JLA process:First, an online survey of people living with PsA, carers, and clinicians to identify PsA questions, asking, "What do you think are the most important unanswered questions in psoriatic arthritis research? ". The questions were checked against existing evidence to establish "true uncertainties " and grouped as "indicative questions " reflecting the overarching themes. Then a second online survey ranked the "true uncertainties "by importance. Finally, a workshop including people living with PsA and clinician stakeholders finalised the top 10 research priorities. Results: The initial survey attracted 317 respondents (69% people living with PsA, 15% carers), with 988 questions. This generated 46 indicative questions. In the second survey, 422 respondents (78% people living with PsA, 4% carers) prioritised these. Eighteen questions were taken forward to the final online workshop. The top unanswered PsA research question was "What is the best strategy for managing patients with psoriatic arthritis including non-drug and drug treatments? ". Other Top 10 priorities covered diagnosis, prognosis, outcome assessment, flares, comorbidities and other aspects of treatment (https://www.jla.nihr.ac.uk). Conclusion: The top 10 priorities will guide PsA research and enable PsA researchers and those who fund research to know the most important questions for people living with PsA.