MEMORY RECONSOLIDATION AFTER LEARNING OF DIFFERENT INTENSITY DEPENDS ON THE DURATION OF THE REMINDER INTERVAL

Two series of experiments on elaboration of a conditioned reflex to the situation in a terrestrial snail were carried out using two learning protocols with different numbers of unconditioned stimuli. In each experimental series, to initiate memory reconsolidation, a "reminder" of the learning environment was performed at different times - on the 3rd and 6th days after training, followed by blockade of protein synthesis with anisomycin. The procedure of "reminder" of the learning environment in combination with the injection of anisomycin, performed on the 3rd day after training according to both protocols, led to impaired memory reconsolidation (forgetting). However, when the learning environment was "reminded" on the eh day after training, followed by blockade of protein synthesis memory, the retention of memory was observed in animals that received less reinforcement during training. At the same time, in animals that received more reinforcement during training, the "reminder" led to impaired memory reconsolidation (forgetting). Thus, it is shown that reconsolidation of contextual memory in the terrestrial snail depends on the intensity of learning associated with the choice of an intensity of learning protocol with different unconditional stimuli. An assumption was made about different neural pathways for the processes of consolidation and reconsolidation.