Silver - calcium titanate - titania decorated Ti6Al4V powders: An antimicrobial and biocompatible filler in composite scaffold for bone tissue engineering application

The present work describes a technique to develop silver nanoparticles decorated calcium titanate-titania (AgNPs-CT-TiO2) nanostructured layer over Ti6Al4V alloy powder by simple chemical and heat treatment approach. The NaOH solution and heat treatment form a uniform porous nano-network morphology of sodium titanate and subsequent calcium nitrate treatment transforms it into calcium titanate along with rutile TiO2. However, simultaneous treatment with calcium and silver nitrate solution allows the incorporation of both calcium and silver ions over the nano-network morphology leading to the formation of AgNPs decorated calcium titanate along with anatase TiO2 (AgNPs-CT-TiO2@Ti6Al4V) that collectively induces biocompatibility towards MG 63 osteoblast-like cells as well as antimicrobial activity against Staphylococcus aureus. Thus modified AgNPs-CT-TiO2 @Ti6Al4V alloy powders were subsequently blended with polymethyl methacrylate to develop a composite scaffold using NaCl as a porogen. This composite could be used as a scaffold or bone cement in various bone tissue engineering applications. (C) 2021 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.