A delicate approach to the determination of duloxetine hydrochloride using electrospun polyvinylidene difluoride nanofibers

A simple and delicate approach was developed for the determination of duloxetine hydrochloride using electrospun polyvinylidene difluoride (PVDF) nanofibers. Synthesis of PVDF-based electrospun nanofibers was monitored by ultraviolet visible (UV) spectrophotometer. The characterization was carried out by atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy. AFM images showed that the size of synthesized PVDF electrospun nanofibers ranged in between 20 and 340 nm, while the presence of different functional groups was confirmed by FTIR spectroscopy. The synthesized PVDF electrospun nanofibers were applied for the determination of duloxetine hydrochloride. For the determination of duloxetine hydrochloride, a calibration of the standards of known concentration of duloxetine hydrochloride ranging from 1 to 10 mg/L in PVDF electrospun nanofibers solution against their UV absorbance was developed. Excellent regression coefficient ( R 2 = 0.994) was achieved from the linear calibration curve with 0.48 and 1.6 mg/L of LOD and LOQ, respectively. Results of the study clearly indicated that electrospun nanofibers obtained through PVDF could be used for an accurate determination of duloxetine hydrochloride.