Hollow nanosphere-doped bacterial cellulose and polypropylene wound dressings: Biomimetic nanocatalyst mediated antibacterial therapy

Reactive oxygen species (ROS) have been demonstrated to be an effective substance for combating bacterial infections. Inspired by the biocatalytic ability of nanozymes in regulating ROS levels, nanozyme-based wound dressing with intelligent ROS mediating ability is a promising therapeutic strategy for combating bacterial infections in wounds. Herein, a hollow mesoporous nanocatalyst (Fe@HCMS) assembled with glucose oxidase (GOx) with multienzyme-mimicking activity was developed. The designed Fe@HCMS can effectively catalyze physiological levels of glucose into highly reactive hydrogen radicals via a self-triggered cascade reaction, which resulted in remarkable antibacterial ability. To address the limits of nanozymes in wound treating, a novel antibacterial wound dressing was fabricated by assembling the prepared nanocatalyst on the biosynthesized bacterial cellulose (BC) enveloped polypropylene (PP) composites. The BC layer on PP nonwoven fabrics was produced with PP serving as the scaffold in the culture medium for BC formation, which endowed the prepared dressing outstanding moisture retention ability. The nanozyme-based wound dressing possesses outstanding breathability, remarkable biocompatibility and bacteria inactivation ability, as well as could significantly inhibit the biofilm formation. Further, in vivo study demonstrated it can effectively promote wound healing caused by bacterial infections, which has a great potential for ROS mediated biocatalytic therapy.