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Shalini Narayana,Crystal G. Franklin,Elizabeth Peterson,Eric Hunter, Donald A. Robin, Angela Halpern, Jennifer Spielman,Peter T. Fox, Lorraine O. Ramig

Human Brain Mapping(2022)

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摘要
COVER ILLUSTRATION Neural changes accompanying dosage intensive treatments targeting voice or articulation in patients with Parkinson's dysphonia. Voice treatment (yellow) targeted larynx and respiration while articulation treatment (blue) targeted mouth and lips. Behaviorally, voice treatment but not articulation treatment resulted in improvement in voice quality. However, treatment target specific changes in the speech motor network were observed during a reading task immediately following each treatment. Brain areas altered by voice treatment are shown in yellow and brain areas showing changes following articulation treatment are shown in blue. Left hemisphere activations are clear and right hemisphere activations are checkered. Voice treatment increased activity in left premotor and bilateral auditory cortices while articulation treatment increased activity in bilateral premotor and left insular cortices. The intensive dosage contributed to persistent changes at 7-month follow up. These results indicate that dysphonia and the speech motor network can be differentially modified by treatment targets, while intensive dosage contribute to long lasting effects of speech treatments.
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