Femtosecond lasers structured titanium implant in regulating bacteria and bone stem cell adhesion

Biological complications related to bacterial engraftment on rough titanium are an issue in design of new functionalized implants. By fine-tuning femtosecond lasers (FSL) parameters, we aim to design multiscale (micro- + nano-scale) textured surfaces maintaining osteo-integration with unique antibacterial properties. Titanium samples (Ti6-Al4V) are irradiated at 1030-515-257 nm wavelengths to produce various types of Laser-Induced Periodic Surface Structures (LIPSS). We revealed that LIPSS periodicity and morphology (linear or radial) are determinant for anti-bacterial properties. Preliminary results on multiscale surfaces reveal that cell adhesion of bone stem cells is maintained. FSL appears then as an innovative tool to produce dual-functionalized surfaces.